Monday Night Football Betting Primer San Francisco 49ers @ Arizona Cardinals (+10 | O/U: 43)

Matchup Preview

NFC West rivals meet in Mexico City, as the San Francisco 49ers look to continue their winning ways vs the Arizona Cardinals. Backup QB Colt McCoy will once again start for Arizona, but he has performed admirably in this spot, boasting a perfect 3-0 record as the Cards’ backup on the road. Further, despite his shortcomings HC Kliff Kingsbury has an exceptional 20-8-2 ATS record away from home in his Arizona tenure. Keen bettors are aware of the allure in backing Kingsbury in this spot, however doing so blindly against the 49ers would be unwise. 


The 49ers boast elite talent at nearly every position, and will hold matchup advantages across the board in tonight’s game. San Francisco has rightfully emerged as a popular pick to win the NFC, and can claim the NFC West lead with a victory tonight. There are few who would pick against the 49ers to win this game outright, but San Fran and QB Jimmy Garoppolo have historically struggled under the weight of expectations, and in any game against the Cardinals.


San Francisco was favored by 8 points over the weekend, and such line movement their way should signal them to be the side to back tonight-- but is there still value in the number?. Further, it has historically been a layup to back the favorite in international games, but should we expect this to be the case tonight?

Active Trends

San Francisco 49ers Trends

  • Since 2005, favorites of seven or more points are 8-3-1 ATS at Neutral Sites

  • In NFL international games, the favorite has gone 23-14 ATS

  • Jimmy Garoppolo is 2-8 ATS as a regular season favorite of seven or more points

  • The 49ers are 13-6-1 to the Under in their last twenty games

Arizona Cardinals Trends

  • Kliff Kingsbury is 9-12 ATS vs the NFC West 

  • Kliff Kingsbury is 20-8-2 ATS on the road in the regular season

  • Kliff Kingsbury is 4-1-1 ATS vs Kyle Shanahan

  • Arizona is 6-1-1 ATS in their last eight vs San Francisco

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